Fabrication of an anthropomorphic heterogeneous mouse phantom for multimodality medical imaging.

Fabrication of an anthropomorphic heterogeneous mouse phantom for multimodality medical imaging. Phys Med Biol. 2018 Sep 05;: Authors: Zhang H, Hou K, Chen J, Dyer BA, Chen JC, Liu X, Zhang F, Rong Y, Qiu J Abstract This work is to present a comprehensive methodology for constructing a tissue equivalent mouse phantom using image modeling and 3D printing technology. The phantom can be used in multimodality imaging and irradiation experiments, quality control, and management. Computed Tomography (CT) images of a mouse were acquired and imported into 3D modeling software. A skeleton and a skin shell models were segmented in the modeling software and manufactured using 3D printing technology. The bone model was constructed with VERO-WHITE printing material with additional ingredients, including a photosensitive resin, polyurethane epoxy resin, and acrylate. Acrylonitrile Butadiene Styrene (ABS) resin material was used to construct the skin shell. The skin shell was attached to the skeleton and filled with a specially formulated gel to act as a soft tissue substitute. The gel consisted of agarose, micro-pearl powder, sodium chloride, and magnevist solution (gadopentetate dimeglumine). A micro-container filled with 18F-fluorodeoxyglucose (18F-FDG) radioactive tracer was placed in the abdomen for micro & human positron emission tomography (PET)/CT imaging. The mouse phantom had tissue equivalency in dose attenuation with X-rays and rela...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research