Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

Publication date: 6 September 2018Source: Cell, Volume 174, Issue 6Author(s): Haiyang Yu, Don W. ClevelandPartial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.
Source: Cell - Category: Cytology Source Type: research