Metabolic Frugality Marks Cancer Cells for Immune Targeting

Publication date: 6 September 2018Source: Cell, Volume 174, Issue 6Author(s): Lucas B. SullivanAltered cell metabolism is ubiquitous in cancer cells; however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer cells for recognition by immunotherapy.
Source: Cell - Category: Cytology Source Type: research