Neuronal Growth Factor regulates brain specific kinase 1 expression by inhibiting promoter methylation and promoting Sp1 recruitment

In conclusion, our results provide evidence of a novel mechanism of Brsk1 transcriptional regulation changing the promoter's methylation status, which was incited by the NGF-induced neuronal differentiation process.

Source: Neurochemistry International - September 7, 2018 Category: Neuroscience Source Type: research