E-Selectin/AAV Gene Therapy Promotes Wound Healing in a Critical Limb Ischemia Mouse Model

Poor wound healing in critical limb ischemia (CLI) has been attributed to impaired neovascularization and diminished reperfusion. Optimizing the wound microenvironment by priming wound tissue with adhesion molecules to enhance stem and progenitor cell homing for wound healing may revolutionize the treatment of ischemic wounds. The primary aim of this study involves testing the efficacy of adhesion molecule E-selectin on ischemic wound healing in an ischemic mouse wound model, appraising the possibility of E-selectin-based gene therapy for wound care in CLI.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts Presented to the Florida Vascular Society Source Type: research