Chemical constituents from Anthocleista liebrechtsiana De Wild & T. Durand (Loganiaceae)

Publication date: December 2018Source: Biochemical Systematics and Ecology, Volume 81Author(s): Francis T. Ngouafong, Roland T. Tchuenguem, Jonas Kühlborn, Beaudelaire K. Ponou, Rémy B. Teponno, Jean P. Dzoyem, Till Opatz, Léon A. TapondjouAbstractA new steroid derivative, (24S)-3β-hydroxy-7β-methoxyergost-5-ene (1), was isolated along with eleven known compounds: 7α-hydroxysterol (2), β-sitosterol (3), oleanolic acid (4), betulinic acid (5), lupeol (6), swertiaperennin (7), decussatin (8), tetracosanoic acid (9) β-sitosterol-3-O-β-d-glucopyranoside (10), (2R,3S)-2,3-dihydro-2-(3,4-dimethoxyphenyl)-3-hydroxymethyl-5-(2-formylvinyl)-7-hydroxybenzofuran (11) and acacetin 6-C-β-d-glucopyranoside (12) from the tree bark and leaves of Anthocleista liebrechtsiana De Wild & T. Durand. Their structures were elucidated on the basis of spectroscopic (1D and 2D NMR) and mass spectrometric data. Compounds 2 and 7–10 have already been isolated from the genus Anthocleista and 3–6 from the Loganiaceae family. The isolated secondary metabolites were screened for their antimicrobial properties but only compound 12 showed moderate activity against Pseudomonas aeruginosa. Furthermore, the chemotaxonomic significance among Anthocleista species is discussed.Graphical abstract

Source: Biochemical Systematics and Ecology - September 6, 2018 Category: Biochemistry Source Type: research