The Trem2 R47H Alzheimer ’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer ’s disease. Mouse models accurately reproducing phenotypes observed in ...

Source: Molecular Neurodegeneration - September 6, 2018 Category: Neurology Authors: Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock and Christian Haass Tags: Research article Source Type: research