Paeoniflorin extract reverses dexamethasone-induced testosterone over-secretion through downregulation of Cytochrome P450 17A1 expression in primary murine theca cells

ConclusionsPFE may reduce over-secretion of testosterone in theca cells through downregulation of CYP17A1 and CYP11A1. These findings provide scientific evidence to treat PCOS with the root of Paeonia lactiflora Pall.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research