Early Life Status Epilepticus and Stress Have Distinct and Sex-Specific Effects on Learning, Subsequent Seizure Outcomes, Including Anticonvulsant Response to Phenobarbital.

CONCLUSIONS: Early life 3KA-SE and maternal separation cause more but transient cognitive deficits in males but aggravate the consequences of subsequent lithium-pilocarpine SE in females. In contrast, on flurothyl seizures, EL events showed either beneficial or no effect, depending on gender, type, and age at EL events. PMID: 25311088 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25311088?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - October 14, 2014 Category: Neuroscience Authors: Ozlem A, Moshé SL, Galanopoulou AS Tags: CNS Neurosci Ther Source Type: research