Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3.

CONCLUSION: Our data demonstrated, for the first time, that CA might represent a novel drug candidate for the development of an anti-CRPC therapy.
PMID: 30176898 [PubMed - in process]

Source: Clinical Prostate Cancer - September 3, 2018 Category: Cancer & Oncology Authors: Ma B, Zhang H, Wang Y, Zhao A, Zhu Z, Bao X, Sun Y, Li L, Zhang Q Tags: J Exp Clin Cancer Res Source Type: research