Growing out of attention deficit hyperactivity disorder: insights from the ‘remitted’ brain

Publication date: Available online 5 September 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Gustavo Sudre, Aman Mangalmurti, Philip ShawAbstractWe consider developmental and cognitive models to explain why some children ‘grow out’ of attention deficit hyperactivity disorder (ADHD) by adulthood. The first model views remission as a convergence towards more typical brain function and structure. In support, some studies find that adult remitters are indistinguishable from those who were never affected in the neural substrates of 'top-down' mechanisms of cognitive control, some 'bottom-up' processes of vigilance/response preparation, prefrontal cortical morphology and intrinsic functional connectivity. A second model postulates that remission is driven by the recruitment of new brain systems that compensate for ADHD symptoms. It draws support from demonstrations of atypical, but possibly beneficial, patterns of connectivity within the cognitive control network in adult remitters. The final model holds that some childhood ADHD anomalies show lifelong persistence, regardless of adult outcome, supported by shared reports of anomalies in remitters and persisters in posterior cerebral and striato-thalamic regions. The models are compatible: different processes driving remission might occur in different brain regions. These models provide a framework for future studies which might inform novel treatments to 'accelerate' remission.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Authors: Sagiadinou M, Plerou A Abstract Neurofeedback video games respond to electrical brain signals instead to a mouse, joystick, or game controller input. These games embody the concept of improving physiological functioning by rewarding specific healthy body signals with success at playing a video game. In this paper, a threefold framework in reference to attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD) treatment blending with neurofeedback techniques and video game implementation is presented. In particular, the specifications of a neurofeedback-based video game for childre...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractPolypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of pharmacokinetic drug –drug interactions (DDIs) and subsequent adverse safety outcomes. Clinically relevant pharmacokinetic DDIs can be prevented by adjusting the dose of the ADHD drug or, if possible, by using an alternative drug that would not have a pharmacokinetic effect on the ADHD drug.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Condition:   Attention Deficit Disorder With Hyperactivity Interventions:   Other: NEUROFEEDBACK;   Other: CONTROL Sponsors:   University Hospital, Geneva;   University of Geneva, Switzerland Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
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Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research
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Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
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Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
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Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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