Cerebrospinal fluid monoamine metabolite concentrations in depressive disorder: A meta-analysis of historic evidence

Publication date: Available online 4 September 2018Source: Journal of Psychiatric ResearchAuthor(s): Shintaro Ogawa, Shoko Tsuchimine, Hiroshi KunugiAbstractAltered monoaminergic functions have been implicated in the pathophysiology of depressive disorder. However, previously reported cerebrospinal fluid (CSF) monoamine metabolite concentrations in major depression have been inconsistent. We performed a meta-analysis of historic evidence to determine whether CSF monoamine metabolite levels were different between patients with depression and normal controls, and could be used as depression biomarkers. Relevant studies that investigated CSF 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in patients with depression and normal controls were identified in the PubMed, Web of Science, PsycINFO, and Embase databases through September 5, 2017, using a synonymous search for depression, CSF, normal, control, and each monoamine metabolite name, and in the reference lists of the acquired articles. Obtained records were individually scrutinized for eligibility. Our search strategy identified 26 studies, including our own. We employed random effects modeling and adopted “Hedges's g” as an index of effect size. In meta-analyses, no significant difference was observed in the CSF 5-HIAA or MHPG level between patients with depressive disorder and controls. In contrast, the CSF HVA levels were significantly decreased in depress...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research