Zebrafish models of epigenetic regulation of CNS functions.

Zebrafish models of epigenetic regulation of CNS functions.
Brain Res Bull. 2018 Sep 01;:
Authors: Lakstygal AM, de Abreu MS, Kalueff AV
Abstract
Epigenetic regulation has become a key focus of neuroscience and biopsychiatry, implicating DNA methylation, histone modification and other epigenetic mechanisms in various CNS disorders. Animal (experimental) models are a useful tool for epigenetic studies. Although most such research has been performed in rodents, the zebrafish (Danio rerio) is rapidly emerging as a new promising model organism in neuroscience. These fish are particularly suitable for epigenetic studies due to their fully sequenced genome, easiness of genetic analyses and high physiological and genetic homology with humans. Here, we discuss mounting evidence of epigenetic regulation of CNS functions in zebrafish, and outline future directions of translational research in this field.
PMID: 30179679 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - September 1, 2018 Category: Neurology Authors: Lakstygal AM, de Abreu MS, Kalueff AV Tags: Brain Res Bull Source Type: research