Cancers, Vol. 10, Pages 311: Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer

Cancers, Vol. 10, Pages 311: Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer Cancers doi: 10.3390/cancers10090311 Authors: Hang-Kang Chen Shu-Mei Zhang Junn-Liang Chang Hsin-Chien Chen Yi-Chun Lin Cheng-Ping Shih Huey-Kang Sytwu Mei-Cho Fang Yuan-Yung Lin Chao-Yin Kuo Ai-Ho Liao Yueng-Hsiang Chu Chih-Hung Wang The use of cisplatin (CDDP), the most common chemotherapy drug for head and neck cancer, is limited by its undesirable side effects, especially nephrotoxicity. We investigated ultrasound microbubbles (USMB) as a tool to increase the local intra-tumoral CDDP level while decreasing systemic CDDP cytotoxicity. We allowed CDDP to interact with human serum albumin and then sonicated the resulting CDDP‒albumin complex to generate CDDP-loaded MBs (CDDP-MBs). We then established a head-and-neck tumor-bearing mouse model by implanting FaDu-fLuc/GFP cells into severe combined immunodeficiency mice and used IVIS® bioluminescence imaging to determine the tumor xenograft formation and size. Twice weekly (until Day 33), we administered CDDP only, CDDP + MBs + US, CDDP-MBs, or CDDP-MBs + US intravenously by tail-vein injection. The US treatment was administered at the tumor site immediately after injection. The in vivo systemic distribution of CDDP indicated that the kidney was the most vulnerable organ, followed by the...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research