The impact of a hematopoietic stem cell transplantation on dental development

Hematopoietic stem cell transplantation (HSCT) is currently the only treatment with curative potential for various malignant and nonmalignant disorders [1]. In preparation for HSCT, patients are conditioned with chemotherapy, irradiation, and /or serotherapy to eliminate residual malignant cells, prevent acute and chronic graft versus host disease and facilitate engraftment. Chemotherapy based preparative regimens often contain alkylating drugs such as cyclophosphamide or busulfan [1, 2]. Total body irradiation (TBI) based preparative regimens are used exclusively in children older than 3 years and only for malignant disorders [1].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research