Optimizing Prehospital Triage for Patients With Stroke Involving Large Vessel Occlusion

The past 20 years have witnessed a revolution in the paradigm of acute ischemic stroke treatment. In 1996, intravenous alteplase was shown to improve outcomes among patients treated within 3 hours of stroke onset. This finding upended the historical therapeutic nihilism about stroke, and with it the leisurely armchair approach to stroke treatment. The concept of so-called acute ischemic stroke emerged. This changed the nature and practice of vascular neurology, created a vigorous and sometimes controversial debate between vascular neurologists and emergency physicians about the merits of alteplase, and paved the way for more effective methods of reperfusion in stroke, particularly for strokes arising from proximal large vessel occlusion (LVO). This was accompanied by an intense public education campaign for individuals to engage emergency medical services (EMS) for suspected stroke and a method to certify hospitals capable of delivering intravenous alteplase rapidly and safely.
Source: JAMA Neurology - Category: Neurology Source Type: research

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Publication date: Available online 22 September 2020Source: NeuroscienceAuthor(s): Qian Jiang, Xiaokun Geng, Johnathan Warren, Eric Eugene Paul Cosky, Shawn Kaura, Christopher Stone, Fengwu Li, Yuchuan Ding
Source: Neuroscience - Category: Neuroscience Source Type: research
We report a case of ischemic stroke in the area of a DVA after minor...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Nature Reviews Neurology, Published online: 23 September 2020; doi:10.1038/s41582-020-00417-0Despite the strong treatment effects of mechanical thrombectomy in acute ischaemic stroke, penumbral tissue loss before recanalization and ischaemia–reperfusion injury after diminish functional outcomes and call for adjunct treatments. Classical neuroprotection strategies could consequently be revived, but novel treatment targets are also emerging through mechanistic research.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ ELECTROPHYSIOLOGY Source Type: research
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Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Authors: Banham ND, Saw J, Hankey GJ, Ghia D Abstract A 75 year-old male developed features of an acute stroke following bubble contrast echocardiography, which was shown on emergent computed tomography scanning to be a result of cerebral arterial gas embolism (CAGE) to the left middle cerebral artery. Ischaemic stroke symptoms have previously been reported as a rare complication of bubble contrast echocardiography. Radiologically proven CAGE from bubble contrast echocardiography had not been reported at the time this case occurred. Immediate provision of 100% oxygen and administration of hyperbaric oxygen are reco...
Source: Diving and Hyperbaric Medicine - Category: Sports Medicine Tags: Diving Hyperb Med Source Type: research
Condition:   Stroke, Ischemic Interventions:   Other: Traditional physical therapy balance exercise;   Other: proprioception based balance training Sponsor:   Riphah International University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Pan H, Zhao R, Liu FD, Wu YL, Li GF, Shi YH, Liu YS, Zhao Y, Zhuang MT, Hou TY, Zhang QT, Yao Q, Qiao Y, Huang RJ, Chen LN, Zhu YM, Shu L, Su JJ, Fang J, Tang XM, Wang S, Cui GH, Wang DZ, Liu JR Abstract Our aim was to investigate factors predicting blood pressure (BP) variability during diagnostic cerebral angiography and associations between BP variability and clinical outcomes in patients with acute and subacute ischemic stroke and intracranial artery stenosis. 114 patients with ischemic stroke and intracranial artery stenosis (stenosis rate>50%) were recruited. Patients who underwent cerebral angiog...
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
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