Inovio launches Ph1 study of Hep C vaccine

Inovio Pharmaceuticals (NSDQ:INO) and its partner, GeneOne Life Science (KSE:011000), said today that the companies have dosed the first patient in a Phase I study designed to test a preventive vaccine against hepatitis C infection. The companies plan to recruit 24 study participants to evaluate Inovio’s GLS-6150 candidate. Participants will include people who have a sustained virologic response following treatment for Hep. C, as well as healthy controls. They are slated to receive one of two doses of vaccine, administered intra-dermally and followed by electroporation with Inovio’s Cellectra device. Get the full story at our sister site, Drug Delivery Business News. The post Inovio launches Ph1 study of Hep C vaccine appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Drug-Device Combinations Pharmaceuticals Wall Street Beat Inovio Pharmaceuticals Source Type: news

Related Links:

Around 71 million people worldwide are infected with the hepatitis C virus (HCV) [1]. Up to 80% of infected individuals are unable to clear the virus and persistently infected individuals have a high risk to develop liver cirrhosis and hepatocellular carcinoma. Direct-acting antivirals (DAA) profoundly increased treatment efficiency, but a prophylactic vaccine required for the global control of new HCV infections is not available.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Publication date: January 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 1Author(s): Vivek Soi, Chantale Daifi, Jerry Yee, Elizabeth AdamsAn in-depth understanding of viral hepatitis is important to the care of patients with end-stage renal disease undergoing hemodialysis. Both hepatitis B and C viruses are acquired through hematogenous spread and can lead to horizontal transmission. Concurrent hepatic and renal injuries have ominous outcomes with significant morbidity. Hepatitis B incidence has decreased through practices including vaccination of nonimmune individuals and isolation of patients with the d...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Conclusion: The prevalence of HBV was intermediate according to the endemicity classification by WHO. The practice of SP was poor in most participants and, thus, occupational exposure was high. Therefore, regular screening and vaccination of healthcare workers, regular provision of basic or refresher training and availing logistics, and regular motivation of healthcare workers on the practice of standard precautions are recommended. PMID: 30853866 [PubMed - in process]
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
Despite effective vaccines, hepatitis A virus (HAV) remains a common cause of acute viral hepatitis in many regions of the world [1]. The continued presence of this hepatotropic virus is dependent upon unbroken chains of fecal-oral transmission, since persistent infection is rare-to-nonexistent and chronic HAV shedders are unknown. Accordingly, HAV disappears at times from small, isolated human populations, only to return with a vengeance when re-introduced [2,3]. Thus, unlike hepatitis B virus (HBV) and hepatitis C virus (HCV) that cause longterm persistant infections and co-evolved with humans and other primate species o...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractBackgroundOccupational exposure to blood and body fluids (BBFs) is a serious concern for health care workers (HCWs) and presents a major risk factor for transmission of infectious diseases such as hepatitis B virus (HBV), hepatitis C virus, and human immune deficiency virus. The main objective of this study was to assess the magnitudes of occupational exposure of blood and body fluids and associated factors among health workers at the University of Gondar Hospital.MethodsAn institution-based cross-sectional study was conducted from 1 February to 31 May 2017 at the University of Gondar Hospital. A total of 282 healt...
Source: Environmental Health and Preventive Medicine - Category: Environmental Health Source Type: research
(University of Washington Health Sciences/UW Medicine) A first-of-its-kind nanoparticle vaccine candidate for respiratory syncytial virus, a major cause of infant mortality worldwide, has been developed through computer design. Animal tests suggest the vaccine could provide potent, durable protection against RSV. The vaccine is being further developed for possible clinical trials. The nanoparticle platform will also be used to design potential vaccines for AIDS, hepatitis C and cancer.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Jim Mellon's Juvenescence venture is at present one of the few major venture organizations focused on approaches to treat aging as a medical condition. Mellon and his colleagues outlined their take on the field in a 2017 book, also called Juvenescence. We are fortunate in that he is among the first few high net worth individuals to both agree with the SENS philosophy of damage repair, and then, much more importantly, follow through in action as well as word. He is not just seeing a massive market opportunity in treating aging, though that is certainly there, but is doing this because he wishes to achieve the goal of radica...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
This study included 180 prisoners from the Buca F-Type Closed Prison, and 180 prisoners from the Fo ça Open Prison in Turkey. After the training seminars, serum levels of HBsAg, anti HBs, anti HBc total and anti HCV in the prisoners were assessed using the MICROELISA method. Findings All the prisoners were male. The mean age was 40(21–73) years. According to the results of 360 prisoners from both prisons, 17 (4.7 percent) prisoners were HBsAg positive and were diagnosed as HBV. Isolated anti HBs was positive in 33 (9.1 percent) prisoners who had been previously vaccinated. In 25 (6.9 percent) prisoners isolate...
Source: International Journal of Prisoner Health - Category: Criminology Source Type: research
(BEIJING) — Chinese investigators said Thursday tests on a batch of a plasma product feared to have been contaminated with HIV have turned up negative for the virus that causes AIDS. The result appears to have headed off the possibility of yet another scandal involving medical products in the country. Incidents include the falsifying of production records for rabies vaccines that prompted a nationwide crackdown on the industry and the injecting of other faulty vaccines. Public outrage over such scandals has alarmed the leadership of the ruling Communist Party, moving it to respond more quickly and firmly than in the ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized China onetime Source Type: news
More News: Clinical Trials | Dermatology | Hepatitis | Hepatitis C | Hepatitis Vaccine | Science | Study | Vaccines | Virology