Cancers, Vol. 10, Pages 306: Targeting Raf Kinase Inhibitory Protein Regulation and Function

Cancers, Vol. 10, Pages 306: Targeting Raf Kinase Inhibitory Protein Regulation and Function Cancers doi: 10.3390/cancers10090306 Authors: Ali Ekrem Yesilkanal Marsha Rich Rosner Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research