A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts

Conclusion: Radiolabeled FAPIs allow fast imaging with very high contrast in tumors having a high stromal content and may therefore serve as pantumor agents. Coupling of these molecules to DOTA or other chelators allows labeling not only with 68Ga but also with therapeutic isotopes such as 177Lu or 90Y.

Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Loktev, A., Lindner, T., Mier, W., Debus, J., Altmann, A., Jager, D., Giesel, F., Kratochwil, C., Barthe, P., Roumestand, C., Haberkorn, U. Tags: Translational Source Type: research