Detection Threshold and Reproducibility of 68Ga-PSMA11 PET/CT in a Mouse Model of Prostate Cancer

Conclusion: The in vivo relationship between 68Ga-PSMA11 PET/CT and PSMA expression level in a murine model of prostate cancer was robust for lower cell surface PSMA expression levels (≤22,000/cell). Thus, preclinical 68Ga-PSMA11 PET/CT can be used as an imaging biomarker to test PSMA-targeted interventions in murine models.

Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Luckerath, K., Stuparu, A. D., Wei, L., Kim, W., Radu, C. G., Mona, C. E., Calais, J., Rettig, M., Reiter, R. E., Czernin, J., Slavik, R., Herrmann, K., Eiber, M., Fendler, W. P. Tags: Basic Source Type: research