An Overview of PET Radiochemistry, Part 1: The Covalent Labels 18F, 11C, and 13N

This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel with the nuclides 11C, 13N, and 18F. The overall process of PET tracer production is explained, starting from the production of the radionuclide in a cyclotron; followed by the automatization process of the radiosynthesis, including the necessary steps for the respective synthesis; and finalized with the requirements for quality control.

Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Pichler, V., Berroteran-Infante, N., Philippe, C., Vraka, C., Klebermass, E.-M., Balber, T., Pfaff, S., Nics, L., Mitterhauser, M., Wadsak, W. Tags: Continuing Education Source Type: research