Magnetically targeted photothemal cancer therapy in vivo with bacterial magnetic nanoparticles.

Magnetically targeted photothemal cancer therapy in vivo with bacterial magnetic nanoparticles.
Colloids Surf B Biointerfaces. 2018 Aug 24;172:308-314
Authors: Wang F, Chen C, Chen Y, Wang P, Chen C, Geng D, Li L, Song T
Abstract
The biomineralized bacterial magnetic nanoparticles (BMPs) have been widely studied for biomedical applications with their magnetic properties and a layer of biomembrane. Herein, BMPs were firstly used for magnetically targeted photothermal cancer therapy in vivo. A self-build C-shaped bipolar permanent magnet was used for magnetic targeting though the generation of a high gradient magnetic field within a small target area. For in vitro simulated experiment, BMPs had a high retention rate in magnetically targeted region with different flow rates. In H22 tumor bearing mice, the magnetic targeting induced a 40% increase of BMPs retention in tumor tissues. In vivo photothermal therapy with 808 nm laser irradiation could induce a complete tumor elimination with magnetic targeting. These results indicated that the systematically administrated BMPs with magnetic targeting would be promising for photothermal cancer therapy.
PMID: 30176510 [PubMed - as supplied by publisher]

Source: Colloids and Surfaces - August 24, 2018 Category: Biotechnology Authors: Wang F, Chen C, Chen Y, Wang P, Chen C, Geng D, Li L, Song T Tags: Colloids Surf B Biointerfaces Source Type: research