Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway.

CONCLUSION: These data suggest that CathL acts as an extracellular ligand and plays an important pro-angiogenic, and thus pro-metastatic, role during EOC metastasis to the omentum, by activating the omental microvasculature, and thus can potentially be targeted therapeutically in the future. PMID: 30173647 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30173647?dopt=Abstract

Source: Current Cancer Drug Targets - August 31, 2018 Category: Cancer & Oncology Authors: Pranjol MZI, Gutowski NJ, Hannemann M, Whatmore JL Tags: Curr Cancer Drug Targets Source Type: research