What We Learned From Big Data for Autophagy Research.

What We Learned From Big Data for Autophagy Research. Front Cell Dev Biol. 2018;6:92 Authors: Jacomin AC, Gul L, Sudhakar P, Korcsmaros T, Nezis IP Abstract Autophagy is the process by which cytoplasmic components are engulfed in double-membraned vesicles before being delivered to the lysosome to be degraded. Defective autophagy has been linked to a vast array of human pathologies. The molecular mechanism of the autophagic machinery is well-described and has been extensively investigated. However, understanding the global organization of the autophagy system and its integration with other cellular processes remains a challenge. To this end, various bioinformatics and network biology approaches have been developed by researchers in the last few years. Recently, large-scale multi-omics approaches (like genomics, transcriptomics, proteomics, lipidomics, and metabolomics) have been developed and carried out specifically focusing on autophagy, and generating multi-scale data on the related components. In this review, we outline recent applications of in silico investigations and big data analyses of the autophagy process in various biological systems. PMID: 30175097 [PubMed]
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Front Cell Dev Biol Source Type: research