Notch, BMP and WNT/ β-catenin network is impaired in endothelial cells of the patients with thoracic aortic aneurysm.

In conclusion endothelial cells of the patients with thoracic aortic aneurysm have dysregulated Notch, BMP and WNT/β-catenin related signaling. Shear stress-response and cross-talk between Notch and Wnt pathways that normally ensures aortic integrity and resistance of endothelial cells to stress is impaired in aneurysmal patients.
PMID: 30172576 [PubMed - as supplied by publisher]

Source: Atherosclerosis Supplements - August 25, 2018 Category: Cardiology Authors: Kostina A, Bjork H, Ignatieva E, Irtyuga O, Uspensky V, Semenova D, Maleki S, Tomilin A, Moiseeva O, Franco-Cereceda A, Gordeev M, Faggian G, Kostareva A, Eriksson P, Malashicheva A Tags: Atheroscler Suppl Source Type: research