Synthesis of novel vitamin E containing sulfa drug derivatives and study their antibacterial activity

AbstractA new series of ethoxymethyleneimino sulfa drug (2a–d), alpha-tocopheryl acetamide (5), (N-substituted)sulfamoyl)phenylimino)methyl)alpha-tocopheryl acetamide (6a–d), and (N-substituted)sulfamoyl)phenyl)alpha-tocopheryl acetamide (9a–d) derivatives were synthesized. The newly synthesized compounds were confirmed by spectroscopic tools (IR,1H NMR, and13C NMR, and mass spectra) and evaluated for their antibacterial activities against Gram-positive and Gram-negative bacteria. Gram-negative bacteria,Pseudomonas aeruginosa andSalmonella sp. andEnterococcus italicus showed resistance to all the standard compounds. The compounds5, 6a, and9d were the most potent antibacterial compounds on methicillin-resistantStaphylococcus aureus with MIC range from 0.1 to 0.3  mg/mL and MBC range from 0.2 to 0.4 mg /mL, respectively. The combination between sulfa drugs and vitamin E has proved to be effective antimicrobial activity against the Gram-negative for the first time in addition to Gram-positive bacteria.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research