Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats.

In conclusion, activation of central GALR2 promotes glucose metabolism and ameliorates insulin resistance mainly through the PGC-1α/GLUT4 pathways. The central GALR2 is crucial to whole-body insulin sensitivity and energy homeostasis.
PMID: 30170096 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - August 28, 2018 Category: Drugs & Pharmacology Authors: Fang P, He B, Yu M, Shi M, Zhu Y, Zhang Z, Bo P Tags: Biochem Pharmacol Source Type: research