Quantification of Kinetic Rate Constants for Transcytosis of Polymeric Nanoparticle through Blood-Brain Barrier

ConclusionsOur model results indicate that exocytosis (t12,exo=14.2h) of nanoparticles is seven fold slower to endocytosis (t12,endo=1.9h) suggesting that future studies should focus on enhancing the exocytosis process.General significance.This mathematical study will assist in designing new drug carriers to overcome the drug delivery problems in brain. Furthermore, we anticipate that this model will form the basis of future comprehensive models for drug transport across BBB.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research