Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus

The extensive and unrestricted use of antibiotics has imposed selective pressure on bacteria, resulting in the development of antimicrobial resistance [1]. Antibiotic resistance is considered the greatest threat to the treatment of bacterial diseases by the World Health Organization (WHO) [2]. Among these problematic bacteria, drug-resistant Staphylococcus aureus are responsible for a large number of hospital-acquired infections in many countries [3, 4]. The major mechanisms of bacterial resistance to antibacterial drugs include drug inactivation, target modification, alteration of accessibility to the target through drug efflux and decreased uptake.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research