Cost-effectiveness of a potential anti-tick vaccine with combined protection against Lyme borreliosis and tick-borne encephalitis in Slovenia

This study assessed cost-effectiveness of a potential anti-tick vaccine that would protect against both Lyme borreliosis (LB) and tick-borne encephalitis (TBE) in a highly endemic setting of Slovenia.A Markov model was developed to estimate cost-effectiveness of a vaccine with potential combined protection against LB and TBE from the societal perspective. The model expressed time in annual cycles, followed a target population through their lifetime, and applied an annual discounting of 3%. A target population entered the model in a susceptible state, with time dependent probabilities to acquire LB/TBE. Disease manifestations were either resolved within one cycle, or a patient developed LB/TBE sequelae. The vaccination consisted of initial immunization and one revaccination. Estimates of LB/TBE direct and indirect costs, and data on natural course of LB/TBE were obtained from Slovenian databases. Effectiveness of the vaccine with potential combined protection against LB/TBE was derived from studies on existing TBE and LB vaccines, while utility estimates were collected from various literature sources.A vaccine with potential combined protection against LB/TBE was predicted to have an incremental cost of €771,300 per 10,000 vaccinated persons, an incremental utility of 17QALYs and a base-case incremental cost-effectiveness ratio (ICER) of 46,061€/QALY. Vaccine cost, effectiveness and discount rates were identified as the most influential model parameters. A wholesale ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

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Publication date: Available online 18 March 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Alessandra Ésther de Mendonça, Raiana Gonçalves Moreira, Maria da Penha Henriques do Amaral, Caio Márcio de Oliveira Monteiro, Valéria de Mello, Fernanda Maria Pinto Vilela, Fernanda Cristina Mendonça Homem, John Furlong, Cláudia Dolinski, Márcia Cristina de Azevedo Prata, Evelize Folly das ChagasAbstractThis work aimed to investigate candidate biological control agents against the cattle tick Rhipicephalus microplus by studying three entomopathogenic nematodes (EPN) isolat...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
AbstractThe role of viral load in the outcome of patients requiring hospital admission due to influenza is not well established. We aim to assess if there is an association between the viral load and the outcome in hospitalized patients with a confirmed influenza virus infection. A retrospective observational study including all adult patients who were hospitalized in our center with a confirmed influenza virus infection from January to May 2016. Viral load was measured by real-time reverse-transcriptase –polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on upper respiratory tract samples. Its value was ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractDiagnosing a patient with Zika infection is not always straightforward. Here, we aim to describe our data collected from December 2015 to December 2017 and discuss the implemented algorithm and diagnostic challenges we encountered. At the National Reference Center for Arboviruses at the Institute of Tropical Medicine, Antwerp, Belgium (ITM), a commercial Zika virus (ZIKV) enzyme-linked immunosorbent assay (ELISA) detecting immunoglobulin (Ig) M and IgG, a commercial ZIKV immunofluorescence assay (IFA) detecting IgM, and an in-house Zika virus neutralization test (VNT) were implemented. For molecular detection of ZI...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Purpose: The South Bohemian Region of the Czech Republic is an endemic area of tick-borne encephalitis (TBE). In 2017, the inhabitants of Římov municipality developed a serious course of TBE and Lyme borreliosis (LB). This led experts to research and serology examinations of the inhabitants of Římov in order to detect the seroprevalence of TBE and LB.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.130 Source Type: research
A constant increase in the incidence of tick-borne diseases has been observed in Europe since the last decade of the twentieth century. In Poland, the most common zoonoses transmitted by Ixodes ricinus ticks are tick-borne encephalitis (TBE) and Lyme disease. These diseases have become a serious clinical problem, especially in Podlaskie Region, which is considered an endemic area for these diseases (Czupryna et al., 2011).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
To assess cost-effectiveness of a vaccine that would protect against both Lyme Borreliosis (LB) and tick-borne encephalitis (TBE) in a highly endemic setting in Slovenia.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
Publication date: Available online 6 July 2017 Source:Ticks and Tick-borne Diseases Author(s): Viktor Zöldi, Topi Turunen, Outi Lyytikäinen, Jussi Sane Tick-borne encephalitis (TBE) and Lyme borreliosis (LB) are endemic in Finland, with tens and thousands of cases, respectively, reported annually. We performed a field survey to investigate people’s knowledge, attitudes and practices (KAP) regarding ticks, tick-borne diseases, and prevention strategies. The KAP were assessed using a pre-validated anonymous questionnaire consisting of 39 questions and statements. On two consecutive days in July 2016, conveni...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Abstract Tick-borne encephalitis (TBE) is an arbovirus induced by tick-borne encephalitis virus (TBEV) transmitted by tick bite. The disease is rare in France (two to three cases per year) but endemic zones extend from Western Europe to the east coast of Asia (10,000-15,000 cases per year). An 8-year-old boy was admitted to our pediatric ward in Strasbourg (France) for febrile headache with diplopia. Four days after a tick bite, he declared a febrile headache together with maculopapular rash on the elbows, knees, and cheeks. Fourteen days after the outbreak of symptoms, he showed confusion, drowsiness, and binocul...
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
Publication date: Available online 24 October 2015 Source:Ticks and Tick-borne Diseases Author(s): Jani J. Sormunen, Tero Klemola, Eero J. Vesterinen, Ilppo Vuorinen, Jukka Hytönen, Jari Hänninen, Kai Ruohomäki, Ilari E. Sääksjärvi, Elina Tonteri, Ritva Penttinen Studies have revealed that Ixodes ricinus (Acari: Ixodidae) have become more abundant and their geographical distribution extended northwards in some Nordic countries during the past few decades. However, ecological data of tick populations in Finland are sparse. In the current study, I. ricinus abundance, seasonal questin...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 27 April 2015 Source:Ticks and Tick-borne Diseases Author(s): V. Hönig , P. Svec , P. Halas , Z. Vavruskova , H. Tykalova , P. Kilian , V. Vetiskova , V. Dornakova , J. Sterbova , Z. Simonova , J. Erhart , J. Sterba , M. Golovchenko , N. Rudenko , L. Grubhoffer Spatial distribution of Ixodes ricinus tick host-seeking activity, as well as prevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV) were studied in the TBE endemic area of South Bohemia (Czech Republic). High variability in tick abundance detected in a network of 30 study sites was most close...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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