Medical News Today: How to treat and prevent drool rash

It is common for healthy infants to drool during their first 18 months, especially while teething. However, saliva that comes into contact with the skin may cause irritation and lead to a red, itchy rash. Parents and caregivers can easily treat drool rash using simple home remedies. Learn more in this article.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dermatology Source Type: news

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Recent studies have indicated that the spinal activity of gastrin-releasing peptide (GRP) and its receptor, GRPR, selectively modulate itching behaviors over other somatosensations including pain behaviors. Despite behavioral selectivity, how GRP acts within the spinal cord to selectively convey itch to the brain is not understood. Utilizing a novel ex vivo somatosensory preparation, retrograde labeling of spinal projection neurons, and multiphoton Ca2+ imaging, the activity of excitatory interneurons and projection neurons in the ex vivo spinal cord can be recorded in response to natural stimulation of the skin and pharma...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Dissecting the spinal circuitry of pain and itch has been limited by a lack of genetic tools to label discrete subpopulations of spinal neurons. In particular, markers for spinal projection neurons are lacking, and thus the contributions of spinal projection neurons to somatosensation are largely unknown. Currently the only known marker for spinal projection neurons is neurokinin-1 receptor (NK1R), which captures the majority of spinal projection neurons. While neurotoxic ablation studies have provided evidence demonstrating the importance of NK1R spinal projection neurons to itch and hyperalgesia, interpretation of these ...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Itch is defined as an unpleasant sensation that evokes a desire to scratch. The supraspinal mechanisms that are engaged in itch processing are largely unknown. Here we took an unbiased approach using immediate early gene (cFos) mapping for precise dissection of brain circuits that mediate itch processing. These studies identified the central nucleus of the amygdala (CeA) as a region robustly engaged during itch/scratching. To explore this directly, we recorded real time calcium dynamics using fiber photometry in freely behaving mice and found that scratching led to robust increase in CeA neuronal activity in animals expose...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
In this study, we use a semi intact, ex vivo preparation to investigate the role of a population of dorsal horn interneurons that express neuronal nitric oxide synthase (nNOS) in local spinal microcircuitry.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Pain and itch are two somatosensory modalities whose pathologic manifestations cause immense suffering and health burden to millions of people worldwide. Mu-opioid ligands and analogs have been the mainstream therapy against pain, but due to their significant side effects there is an urgent need to have a deeper understanding of the signaling of opioid receptors and to identify newer drug targets which could help improve treatment for these pathologies. G β5 is a divergent member of the Gβ subunits of heterotrimeric G proteins which are unique in binding the Gγ like domain present in the R7- RGS proteins.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Molecular and Cellular Biology (with CE) Source Type: research
Authors: De Vloo C, Nevens F Abstract Pruritus is a common, troublesome symptom in patients with cholestatic liver diseases, especially frequent in intrahepatic cholestasis of pregnancy (ICP) and in primary biliary cholangitis (PBC). Cholestatic associated pruritus can have profound effects on the quality of life. The underlying mechanism is still poorly understood. Severe potential pruritogens have been discussed, such as bile salts, opioids, steroid and lysophosphatidic acid (LPA), but none of these are considered as key mediators. Because of this unraveling pathophysiology the treatment of hepatogenic pruritus o...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Robots that help severely disabled people are generally assumed to have to be super smart, capable of replacing human caretakers. Engineers at Georgia Tech decided to take a very different approach, instead empowering disabled people to control ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Psychiatry Rehab Source Type: blogs
BED BUG bites are most common when you ’re sleeping, and cause itchy, red bumps all over the skin. You could be at risk of a bed bugs infestation if your bedroom has a distinctive smell. These are the warning signs to look out for, and how to get rid of bed bugs.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Updated Date: Mar 19, 2019 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
(Natural News) Scientists have found a new way to relieve itchy skin without resorting to potentially harmful scratching. An experimental method devised by Italian researchers used a certain type of light to get rid of itchiness and prevent the annoying sensation from coming back for months afterward. Most people know the annoying experience of suddenly needing to scratch a particularly...
Source: - Category: Consumer Health News Source Type: news
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