Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

Conclusions These data indicate that reduced phosphorylation of ACC after renal injury contributes to the development of TIF, and that phosphorylation of ACC is required for metformin’s antifibrotic action in the kidney.

http://jasn.asnjournals.org/cgi/content/short/29/9/2326?rss=1

Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Lee, M., Katerelos, M., Gleich, K., Galic, S., Kemp, B. E., Mount, P. F., Power, D. A. Tags: Basic Research Source Type: research