A Patient-Independent Significance Test by Means of False-Positive Rates in Selected Correlation Analysis of Brain Multimodal Monitoring Data.

A Patient-Independent Significance Test by Means of False-Positive Rates in Selected Correlation Analysis of Brain Multimodal Monitoring Data. Comput Math Methods Med. 2018;2018:6821893 Authors: Faltermeier R, Proescholdt MA, Wolf S, Bele S, Brawanski A Abstract Recently, we introduced a mathematical toolkit called selected correlation analysis (sca) that reliably detects negative and positive correlations between arterial blood pressure (ABP) and intracranial pressure (ICP) data, recorded during multimodal monitoring, in a time-resolved way. As has been shown with the aid of a mathematical model of cerebral perfusion, such correlations reflect impaired autoregulation and reduced intracranial compliance in patients with critical neurological diseases. Sca calculates a Fourier transform-based index called selected correlation (sc) that reflects the strength of correlation between the input data and simultaneously an index called mean Hilbert phase difference (mhpd) that reflects the phasing between the data. To reliably detect pathophysiological conditions during multimodal monitoring, some thresholds for the abovementioned indexes sc and mhpd have to be established that assign predefined significance levels to that thresholds. In this paper, we will present a method that determines the rate of false positives for fixed pairs of thresholds (lsc, lmhpd). We calculate these error rates as a function of the predefined thresholds for each...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research