Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology.

In conclusion, the TEP across the RPE depends on the expression of ATP1B1 and this regulates the secretion of PEDF by RPE cells and so may regulate the onset of retinal disease. Increasing the expression of PEDF using an applied EF to replenish a disease or age-reduced TEP may offer a new way of preventing or reversing retinal dysfunction.
PMID: 30160348 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - August 30, 2018 Category: Molecular Biology Authors: Cao L, Liu J, Pu J, Milne G, Chen M, Xu H, Shipley A, Forrester JV, McCaig CD, Lois N Tags: J Cell Mol Med Source Type: research