Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

AbstractTwo new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark ofGarcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds3–6 and8 showed good cytotoxicity against all the five cancer cell lines with IC50 values in the range of 1.45 –9.46 µM.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research