Inhibiting NF- & #954;B improves heart function in a mouse model of Duchenne muscular dystrophy

(Medical University of South Carolina) In an August 24, 2018 article in Nature Communications, investigators at the Medical University of South Carolina and Ohio State University report that nuclear factor kappa B (NF-κB) down-regulates calcium genes, contributing to cardiomyopathy in Duchenne muscular dystrophy (DMD). Murine data show cardiomyocyte ablation of NF-κB rescues cardiac function. NF-κB promotes global chromatin landscape changes that repress calcium mobilization in DMD. This mechanism also contributes to skeletal muscle dysfunction.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news