Evaluation of resection of the gastroesophageal junction and jejunal interposition (Merendino procedure) as a rescue procedure in patients with a failed redo antireflux procedure. A single-center experience

Primary antireflux surgery has high success rates but 5 to 20% of patients undergoing antireflux operations can experience recurrent reflux and dysphagia, requiring reoperation. Different surgical approaches a...
Source: BMC Surgery - Category: Surgery Authors: Tags: Research article Source Type: research

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Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. BE is known as a precursor of esophageal adenocarcinoma. Currently, the molecular mechanism underlying epithelial metaplasia in BE patients remains unknown. Therefore, we investigated the role of Krüppel-like factor 5 (KLF5) signaling in the initiation of BE-associated metaplasia. Sprague-Dawley (SD) rats were used to create a surgical model of bile reflux injury. Immunohistochemistry was performed to analyze human and mouse esophage...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Authors: Gong Y, Zeng Q, Yan Y, Han C, Zheng Y Abstract The aim of this study was to investigate the distribution characteristics of GerdQ results in a Chinese population and the association between lifestyle and GerdQ scores. Among the 37 442 individuals enrolled from September 2009 to March 2016, 7 449 (19.89%) had a GerdQ score of ≥8 points and 29 993 (80.11%) had a GerdQ score of
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
This study simultaneously evaluated the regeneration energy of MDEA and PZ/MDEA solvents in terms of heat of absorption, sensible heat, and vaporization heat. Aspen Hysys version 8.8 simulation tool is applied to model the full acid gas removal plant for the chemical absorption process. The new energy balance technique presents around the absorption and desorption columns to bring a new perspective of energy distribution in the capturing of acid gas plants. Sensitivity analysis of regeneration energy and its three contributors is performed at several operations parameters such as absorber and stripper pressures, lean amine...
Source: Chinese Journal of Chemical Engineering - Category: Chemistry Source Type: research
Condition:   Gastro Esophageal Reflux Intervention:   Procedure: Antireflux Mucosectomy Sponsor:   Chinese University of Hong Kong Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Petcu A, Ghib LJ, Grad SM, Popovici C, Rogojan L, Rednic NV, Rednic S Abstract Gastrointestinal tract involvement is the most common visceral affectation in systemic sclerosis (SSc), but the manifestations may vary in extension and severity. Endoscopic and histopathological gastroesophageal findings were investigated in patients with SSc. A total of 79 consecutive patients with definite SSc were enrolled in a cross sectional study. Clinical data were collected, upper gastrointestinal endoscopy and biopsies from gastric mucosa were performed in all cases. Fifty-seven (72.1%) out of 79 SSc patients had gastr...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Background: High-resolution manometry (HRM) allows characterization of esophagogastric junction (EGJ) morphology and identification of hiatus hernia using novel software tools. Aim: The main purpose of this study was to determine the impact of HRM-based EGJ and lower esophageal sphincter (LES) metrics in predicting abnormal reflux burden. Methods: Total, upright, and supine acid exposure times (AETs) were extracted from ambulatory reflux monitoring performed off therapy in 482 patients (54.2±0.6 y, 63.3% female patients). EGJ morphology was categorized into type 1 (superimposed LES and crural diaphragm), type 2 (
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Goals and Background: Baseline impedance measured during high-resolution impedance manometry (HRIM) can distinguish patients with gastroesophageal reflux disease (GERD) from controls, presumably due to differences in esophageal acid exposure. The characteristics of regurgitation and reflux in rumination syndrome and GERD are very different, and thus we investigated whether baseline esophageal impedance would differ in these 2 patient groups compared with controls. Study: We compared 20 patients with rumination syndrome with 20 patients who had GERD and 40 controls. Baseline impedance was measured over 15 seconds durin...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Background: For eosinophilic esophagitis (EoE) recently an association with immunoglobulin (Ig)G4 rather than IgE has been reported. Gastroesophageal reflux disease (GERD) is the most important differential diagnosis of EoE. We compared esophageal IgG4 plasma cell infiltration and serum IgG4 levels of EoE patients (before and after budesonide therapy) with GERD patients. Methods: Prospectively collected serum samples of 17 EoE patients before and after 8 weeks of therapy with budesonide (1 mg BID) were analyzed for total and antigen-specific IgG4 and IgE levels. Also, immunohistochemical analysis of total and I...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Publication date: Available online 5 December 2019Source: Materials Research BulletinAuthor(s): Jahaziel Amaya, Luis Bobadilla, Lola Azancot, Miguel Centeno, Sonia Moreno, Rafael MolinaAbstractEnhancement of the main physicochemical properties of a natural bentonite was carried out by means of modifications using surfactant, reflux, microwave treatment and, subsequently, the incorporation of AlZr and AlCe species. The evolution of the main changes in each modification stage was evaluated by means of X-ray diffraction, N2 sortometry, scanning microscopy (SEM), NH3-TPD, NH3-DRIFTS and CO adsorption at low temperature. For th...
Source: Materials Research Bulletin - Category: Materials Science Source Type: research
Eosinophilic esophagitis (EoE) is an antigen-driven disease associated with a patchy, pan-esophageal infiltration of eosinophils, mast cells, and T cells. Persistent inflammation triggers dysregulated wound healing that progresses to pathologic tissue remodeling with esophageal rigidity and clinical symptoms of dysphagia and food impactions.1 The most common complaints in adults and teenagers is dysphagia while younger children more commonly have symptoms that mimic gastroesophageal reflux disease like vomiting.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
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