Partial Oral Abx Non-Inferior in Endocarditis on Left Side of Heart
THURSDAY, Aug. 30, 2018 -- Changing from intravenous to oral antibiotic treatment is non-inferior to continued intravenous antibiotic treatment among patients with endocarditis on the left side of the heart, according to a study published online...
New England Journal of Medicine,Volume 380, Issue 25, June 2019.
ConclusionsProphylactic application of iEpo with low tidal volume ventilation for an anticipated complex endocarditis operation may contribute to favorable outcome when compared with postoperative epoprostenol rescue.
AbstractBackgroundContemporary data on mitral valve (MV) surgery in patients with infective endocarditis (IE) are limited.MethodsThe National Inpatient Sample was queried to identify patients with IE who underwent MV surgery between 2003 and 2016. We assessed (a) temporal trends in the incidence of MV surgery for IE, (b) morbidity, mortality, and cost of MV repair vs replacement, and (c) predictors of in ‐hospital mortality.ResultsThe proportion of MV operations involving patients with IE increased from 5.4% in 2003 to 7.3%, and the proportion of MV repair among those undergoing surgery for IE increased from 15.2% to 25.0% (Ptrend
Infective endocarditis (IE) caused by gram-negative bacilli is rare. However, the incidence of this severe infection is rising because of the increasing number of persons at risk, such as patients with immunos...
CONCLUSION: A 36-year-old woman with resistant tricuspid valve endocarditis was successfully treated with linezolid in combination with daptomycin. PMID: 31201773 [PubMed - as supplied by publisher]
ConclusionsInfective endocarditis in patients with CHD is an ongoing clinical challenge. In contemporary practice in tertiary congenital centres, 1/15 patients do not survive to hospital discharge. Streptococci remain the most common causative organism, and antecedent dental or medical procedures were undertaken in a significant minority in the three months before diagnosis. The presence of an atrioventricular septal defect or staphylococcal infection is associated with significantly increased risk of early mortality.
Infective endocarditis (IE) is the microorganism infection of the endocardium known for its high morbidity and mortality in spite of treatment.1 The clinical presentation and outcome are largely determined by the immune and inflammatory response influenced by the host-pathogen interaction. The complex pathogenesis of this condition is a challenge, and understanding the immune-inflammatory cell pathways can be a step closer to improve disease management.
Authors: Leung JSM PMID: 31182677 [PubMed - in process]
Authors: Bitay M, Varga S, Babik B, Havasi K, Szücsborus T Abstract Coronary artery septic embolization is a rare, but severe complication of infective endocarditis involving the leftside of the valves. The first case mentioned in the literature was a postmortem finding of a left anterior descending coronary artery occlusion by a vegetation fragment. Since this case, there have been several therapeutic strategies published with this clinical setting including medical treatment, percutaneous coronary angioplasty addressing coronary occlusion, surgical intervention for both the infected valve and coronary emboli...
Response by Aoyama et al. to Letter Regarding Case Report, "The Early Diagnosis of Endophthalmitis Due to Group B Streptococcus Infective Endocarditis and Its Clinical Course: A Case Report and Literature Review": Vitrectomy or not? Intern Med. 2019 Jun 07;: Authors: Aoyama Y, Oba Y, Hoshide S, Arai Y, Komori T, Kabutoya T, Kario K PMID: 31178522 [PubMed - as supplied by publisher]