Enhanced activity of ADAMTS13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischaemic stroke.

CONCLUSION: The limited proteolytic activity of WT ADAMTS13 in in vitro models of arterial thrombosis suggests an in vivo requirement for conformational activation. The enhanced activity of the GoF ADAMTS13 variant translates to a more pronounced protective effect in experimental stroke. This article is protected by copyright. All rights reserved. PMID: 30152919 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30152919?dopt=Abstract

Source: Thrombosis and Haemostasis - August 28, 2018 Category: Hematology Authors: South K, Denorme F, Salles-Crawley II, De Meyer SF, Lane DA Tags: J Thromb Haemost Source Type: research

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