A Fertility Doctor Used His Sperm on Unwitting Women. Their Children Want Answers.

Donald Cline, an Indiana doctor, may have fathered more than three dozen children. Decades later, they are finding one another through DNA testing sites.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Infertility Artificial Insemination Sperm Pregnancy and Childbirth Frauds and Swindling Indianapolis (Ind) Donald Cline 23andMe Jacoba Ballard Matt White Source Type: news

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Publication date: Available online 16 March 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kai J. Buhling, Annika Schumacher, Christine zu Eulenburg, Elena LaakmannAbstractTo study the evidence of the influence of micronutrient supplementation on male fertility based on published research and to make recommendations for micronutrient supplementation for men suffering from infertility.18 randomised, double-blind, placebo-controlled trials were included in the meta-analysis or in the systematic review.A significant improvement in semen parameters was evident for selenium (200 g orally, daily) and L-carnitine (LC; 2 g ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionThe prevalence of infertility in China is high, but the uptake of treatment is relatively low.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionYounger age, earlier treatment within disease course, fewer cervical canal adhesions, and fewer surgical procedures improve reproductive outcome in patients with severe IUAs and amenorrhea.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Abstract BACKGROUND: The inability to have children affects 10% to 15% of couples worldwide. A male factor is estimated to account for up to half of the infertility cases with between 25% to 87% of male subfertility considered to be due to the effect of oxidative stress. Oral supplementation with antioxidants is thought to improve sperm quality by reducing oxidative damage. Antioxidants are widely available and inexpensive when compared to other fertility treatments, however most antioxidants are uncontrolled by regulation and the evidence for their effectiveness is uncertain. We compared the benefits and risks of...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionsWhile awaiting replication of this study in larger populations, these findings challenge the presumed dominant importance of genetic parenthood. This raises questions about whether donor gametes could be presented as a worthy alternative earlier in treatment trajectories and whether investments in novel treatments enabling genetic parenthood, like in vitro gametogenesis, are proportional to their future clinical impact.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionsIt offers some support for evaluating the effect of pretreatment with Levonorgestrel-Releasing Intrauterine System in women with adenomyosis in future randomized controlled trials(RCTs).
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Semin Reprod Med 2018; 36: 204-210 DOI: 10.1055/s-0038-1677526The use of assisted reproductive technologies (ARTs) has increased significantly in recent years. While this is partially due to improved access for infertile patients, another contribution to the growth of ART utilization is represented by individuals without infertility, who electively chose to freeze their gametes and embryos for future use, before ever attempting conception spontaneously. Overall, the safety of ART for parents and children is well described and the risks are modest. However, while long-term health consequences for offspring as postulated by ...
Source: Seminars in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Review Article Source Type: research
Integrated analyses of phenotype and quantitative proteome of CMTM4 deficient mice reveal its association with male fertility. Mol Cell Proteomics. 2019 Mar 13;: Authors: Liu F, Liu XX, Liu X, Li T, Zhu P, Liu Z, Xue H, Wang W, Yang X, Liu J, Han W Abstract The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family that has been implicated in male reproduction. CMTM4 is an evolutionarily conserved member that is highly expressed in the testis. However, its function in male fertility remains unknown. Here, we demonstrate that CMTM4 is associated wit...
Source: Molecular and Cellular Proteomics : MCP - Category: Molecular Biology Authors: Tags: Mol Cell Proteomics Source Type: research
While IVF can be a very effective treatment option for infertile couples,  the sad truth is that it sometimes causes more harm than good.Thus, many IVF doctors push unproven and untested tests and treatments on their patients. These are disguised in the garb of being the "latest technological advance", but actually serve only to improve the  clinic's profits, and not the patient's pregnancy rates. However, patients are desperate, and unethical doctors are happy to take advantage of the patient's vulnerability.Over the last 30 years, we have seen many of these "advances" come and go. They were ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
AbstractPurposeTo evaluate the efficacy in suppressing the premature LH surge, embryo quality and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) protocols using medroxyprogesterone acetate versus utrogestan in women of all ages undergoing in vitro fertilization or intracytoplasmic sperm injection.Methods1188 patients were enrolled in the retrospective study, of which 1002 patients were treated with medroxyprogesterone acetate (M group) and recombinant follicle-stimulating hormone (r-FSH)simultaneously from day 3 of the cycle until trigger day, while 186 patients were treated with utrogestan (U group) and...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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