Genetically encoded sensor tracks changes in oxygen levels with very high sensitivity

(Tokyo Institute of Technology) Based on a protein from E. coli, scientists at Tokyo Institute of Technology have developed a fluorescent protein sensor able to provide real-time information on dynamic changes in oxygen levels with very high sensitivity. As the oxygen level is a major determinant of cellular function, the idea behind this sensor may revolutionize our ability to detect cellular changes of critical importance, such as in tumors and following stroke and heart attack
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Abdul Wahab Jatoi, Ick Soo Kim, Hiroshi Ogasawara, Qing-Qing NiAbstractAlthough silver based nanofibers possess excellent bactericidal and bacteriostatic characteristics. However, excess release/contact with silver may induce harmful side-effects including carcinoma, argyria, argyrosis and allergies. Similarly, silver depletion may limit prolonged antibacterial activities as well. Thus present research proposes electrospun CA/ZnO/AgNPs composite nanofibers for biologically safer and sustained antibacterial applications. The Zn...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Publication date: Available online 17 August 2019Source: The Annals of Thoracic SurgeryAuthor(s): Niv Ad, Sari D. Holmes, Harold G. Roberts, J. Scott Rankin, Vinay BadhwarAbstractBackgroundSurgical treatment of symptomatic atrial fibrillation (AF) has been performed for three decades. We reviewed trends and outcomes of surgical ablation (SA) for stand-alone AF using the Society of Thoracic Surgeons Adult Cardiac Surgical Database (STS-ACSD).MethodsThe STS-ACSD was reviewed from 2011-2017 (N=7,187) for trends. Contemporary data from 2014-2017 (N=3,893) were used to compare three subgroups: off-pump (n=3,252), on-pump (n=491...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 17 August 2019Source: Food Research InternationalAuthor(s): Alejandra Orihuel, Lucrecia Terán, Jenny Renaut, Sébastien Planchon, María Pía Valacco, Emilse Masias, Carlos Minahk, Graciela Vignolo, Silvia Moreno, André M. De Almeida, Lucila Saavedra, Silvina FaddaAbstractThe enterohemorrhagic Escherichia (E.) coli (EHEC) is a pathogen of great concern for public health and the meat industry all over the world. The high economic losses in meat industry and the high costs of the illness highlight the necessity of additional efforts to control this pathogen. ...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 17 August 2019Source: Journal of BiotechnologyAuthor(s): Susanne Maurer, Hendrik Schewe, Jens Schrader, Markus BuchhauptAbstractFatty aldehydes are among the most important flavor and fragrance compounds. Most biotechnological production approaches make use of the one step conversion of fatty acids from renewable sources by the enzymes α-dioxygenase (αDox) or carboxylic acid reductase (CAR). Their reaction mechanisms and cofactor dependencies are very different. In contrast to heme-containing αDox which requires only oxygen as cosubstrate, CAR needs NADPH and ATP, which ...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 17 August 2019Source: Journal of Organometallic ChemistryAuthor(s): Eva Vaňková, Kristýna Lokočová, Olga Maťátková, Ivana Křížová, Jan Masák, Bohumír Grüner, Pavel Kaule, Jan Čermák, Václav ŠíchaAbstractThe failure of currently used antibiotics in infections treatment caused by still often emerging microbial resistance is one of the most important worldwide research items. Based on the proved biological activities of cobalt bis-dicarbollide anion [1]- and its derivatives in many medical f...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
A previously healthy, well-appearing 42-year-old female living in a modern, high-rise apartment in downtown Los Angeles calls 9-1-1 at 5:30 am complaining of worsening of a burning, epigastric pain she had been experiencing for the last three days. She reports associated nausea and non-bloody, non-bilious vomiting, and that she couldn’t manage to get comfortable in bed until she finally decided to call for help at daybreak. During her 9-1-1 call, she reports “pain, like heartburn, that just woke me up again and I had to throw up, … and then I was sweating so much.” Using the Los Angeles Tiered Disp...
Source: JEMS Special Topics - Category: Emergency Medicine Authors: Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue." Early Onset of Menopause Correlates with Shorter Life Expectancy https://www.fightaging.org/archives/2018/10/early-onset-of-menopause-correlates-with-shorter-life-expectancy/ Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The v...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241 Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03,...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles January 2017 Source Type: research
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