Genetically encoded sensor tracks changes in oxygen levels with very high sensitivity

(Tokyo Institute of Technology) Based on a protein from E. coli, scientists at Tokyo Institute of Technology have developed a fluorescent protein sensor able to provide real-time information on dynamic changes in oxygen levels with very high sensitivity. As the oxygen level is a major determinant of cellular function, the idea behind this sensor may revolutionize our ability to detect cellular changes of critical importance, such as in tumors and following stroke and heart attack
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 22 July 2020Source: NeuroImage: ClinicalAuthor(s): Lena KL Oestreich, Paul Wright, Michael J O'Sullivan
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
HEART attack symptoms include difficulty breathing, severe chest pain, and feeling sick. But, you could also be at risk of a deadly myocardial infarction and heart disease if you develop a tell-tale painful sign in your stomach. Should you consider speaking to a doctor about heart attack signs?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Patients with COVID-19 who present with acute neurologic symptoms may be at...Read more on AuntMinnie.comRelated Reading: AI, radiomics can predict stroke treatment success ECR 2020: COVID-19's nonpulmonary manifestations SNMMI 2020: PET radiotracer measures stroke recovery Researchers outline neurological signs of COVID-19 Imaging shows new, post-SARS-CoV-2 illness in children
Source: Headlines - Category: Radiology Source Type: news
A disease associated with COVID-19 that causes multiple organ failure in children...Read more on AuntMinnie.comRelated Reading: WHO publishes guidance on COVID-19 chest imaging RSNA addresses COVID-19 impact on private practice ECR 2020: COVID-19's nonpulmonary manifestations Kids with SARS-CoV-2 may develop second inflammation Iranian team presents COVID-19 pediatric stroke case
Source: Headlines - Category: Radiology Source Type: news
Abstract Intracerebral hemorrhage (ICH) is one of the most severe subtypes of stroke with high morbidity and mortality. Although a lot of drug discovery studies have been conducted, the drugs with satisfactory therapeutic effects for motor paralysis after ICH have yet to reach clinical application. Transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable cation channel and activated by hypoosmolarity and warm temperature, is expressed in various cell types. The present study investigated whether TRPV4 would participate in the brain damage in a mouse model of ICH. ICH was induced by intrastriatal treatmen...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
This study also demonstrated that TREM-1 expression was upregulated following cerebral infarction in rats. TREM-1 inhibition was determined using its selective inhibitor, LP17, which indicated a neuroprotective effect on cerebral infarction damage. The findings revealed that inhibition of TREM-1 by administering LP17 improved cerebral damage and decreased ischemic areas and brain water contents. Moreover, LP17 decreased MCAO-induced microglial activation and neurodegeneration, evidenced by a reduction in the expression of microglial Iba-1 and FJ-B positive cells, and reversed neuronal loss. Besides, the contribution of LP1...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
A previously healthy, well-appearing 42-year-old female living in a modern, high-rise apartment in downtown Los Angeles calls 9-1-1 at 5:30 am complaining of worsening of a burning, epigastric pain she had been experiencing for the last three days. She reports associated nausea and non-bloody, non-bilious vomiting, and that she couldn’t manage to get comfortable in bed until she finally decided to call for help at daybreak. During her 9-1-1 call, she reports “pain, like heartburn, that just woke me up again and I had to throw up, … and then I was sweating so much.” Using the Los Angeles Tiered Disp...
Source: JEMS Special Topics - Category: Emergency Medicine Authors: Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue." Early Onset of Menopause Correlates with Shorter Life Expectancy Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The v...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03,...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles January 2017 Source Type: research
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