Caries Preventive Effects of High-fluoride vs Standard-fluoride Toothpastes - A Systematic Review and Meta-analysis

Singh, Abhinav / Purohit, Bharathi M.Page 307 - 314Purpose: To determine the efficacy of high-fluoride toothpastes ( ≥ 2500 ppm) as compared to standard fluoride toothpastes (≤ 1500 ppm) in preventing dental caries.Materials and Methods: Randomised controlled trials (RCTs) and cluster-randomised trials comparing high-fluoride dentifrices ( ≥ 2500 ppm) with lower-concentration fluoride dentifrices (≤ 1500 ppm) with a follow-up period of at least 6 months were included. A random effects model was used to assess the mean differences in caries increment between the two types of dentifrices used. A fixed effects model was used to deter mine the preventive effect of high-concentration fluoride toothpastes compared with low-fluoride toothpastes. Subgroup and sensitivity analyses were conducted when results indicated heterogeneity. Statistical significance was set at p
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research