Micro-RNA Genetic Variation Related to Head and Neck Cancer Risk and Survival

Date: Tuesday, 09 25, 2018; Speaker: Brock Christensen, Ph.D., Dartmouth Geisel School of Medicine; https://epi.grants.cancer.gov/events/
Source: NIH Calendar of Events - Category: American Health Source Type: events

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CONCLUSION: This study found that childhood cancer survivors in New Zealand had a high prevalence of developmental dental abnormalities and it identified potential risk factors related to their cancer treatment. Inequitable access to oral rehabilitation for this patient group argues for a mechanism for consistent improved access to publicly funded dental care across district health boards in New Zealand. PMID: 33032302 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Publication date: Available online 8 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): David Tighe, Fabio Fabris, Alex Freitas
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Conclusion: Our findings provide new insights into the role of glycolysis in HNSCC. The identified genes predict the patient prognosis and might substantially contribute to the development of individualized treatments. PMID: 33029143 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
ConclusionWe trained and cross-validated an  RID predictive model with high discriminative ability at both 6 and 12 months after RT. We expect to improve the predictive power of this model by enlarging the number of training datasets.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
This article provides a structured literature review of the most important studies investigating the role of PET or PET/CT in the clinical practice of MCC.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Oropharyngeal cancer is a subtype of head and neck squamous cell carcinoma that is associated with unique risk exposures like consumption of smokeless tobacco and areca nut and is highly prevalent in the northeastern region of India, especially Meghalaya. However, the underlying epigenetic and transcriptomic changes in this cancer type is yet to be delineated. We have undertaken a study on genome wide somatic alterations in the DNA methylation and transcriptome in oropharyngeal cancer patients from this region using genome wide techniques in paired tumors and adjacent normal tissues. By using integrative approaches, we hav...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Most surgical specialities have attempted to address the concern of unfair comparison of outcomes by ‘risk-adjusting’ data in order to benchmark speciality specific outcomes indicative of quality of care. We explore the ability to predict for positive margin status in order that effective benchmarking that accounts for complexity of case-mix is possible.
Source: The British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Authors: Chung PC, Hsieh PC, Lan CC, Hsu PC, Sung MY, Lin YH, Tzeng IS, Chiu V, Cheng CF, Kuo CY Abstract Oral cancer belongs to the group of head and neck cancers. If not diagnosed or treated early, it can be life threatening. Epithelial-mesenchymal transition (EMT) plays an important role in tumor formation and progression. An increase in the presence of the EMT phenotype causes tumor cell proliferation, migration, invasion, and poor prognosis. Therefore, attenuating carcinogenesis via EMT inhibition is a good strategy. Herein, we will determine the pharmacological effects of chrysophanol on the EMT in FaDu cells...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Epstein-Barr virus (EBV) is known as one of the most widespread oncogenic viruses. Head and neck squamous cell carcinoma (HNSCC) is triggered by various risk factors. The aim of the present study was to determine the EBV infection rate, genotyping and variants frequency in HNSCC patients. In this cross-sectional study, 156 patients with HNSCC were enrolled. Formalin fixed paraffin embedded (FFPE) tissue samples were selected from hospitals affiliated to Iran University of Medical Sciences, Tehran, Iran. The EBV EBNA-3C, EBNA-1 and LMP-1 genes were amplified by PCR and then analyzed and confirmed by nucleotide sequencing. C...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Head & Neck cancers Source Type: research
Cancers, Vol. 12, Pages 2877: Regulation of NFκB Signalling by Ubiquitination: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma? Cancers doi: 10.3390/cancers12102877 Authors: Ethan L. Morgan Zhong Chen Carter Van Waes Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with over 600,000 cases per year. The primary causes for HNSCC include smoking and alcohol consumption, with an increasing number of cases attributed to infection with Human Papillomavirus (HPV). The treatment options for HNSCC currently include surgery, radiotherapy, and/or platin...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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