AI Set to Transform Skin Cancer Screening AI Set to Transform Skin Cancer Screening

Advanced algorithms outperform dermatologists at diagnosing some skin cancers, but many questions remain.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Tumor development may be suppressed by the immune system via elimination of cancer cells or via prevention of cancer cell outgrowth. The existence of CD8+CD69+CD103+ tissue resident memory T cells (TRM) and their known role in immune surveillance led Park and colleagues to investigate whether this cell population mediated immunity to epidermis-derived melanoma. Using a mouse model of transplantable melanoma, these investigators demonstrated that tissue-resident TRM established a dynamic melanoma-immune equilibrium in the epidermis, suppressing macroscopic tumor development.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
Abstract Recent clinical studies document the power of immunotherapy in treating subsets of patients with advanced cancers. In this context and with multiple cancer immunotherapeutics already evaluated in the clinic and a large number in various stages of clinical trials, it is imperative to comprehensively examine genomics data to better comprehend the role of immunity in different cancers in predicting response to therapy and in directing appropriate therapies. The approach we chose is to scrutinize the pathways and epigenetic factors predicted to drive immune infiltration in different cancer types using publicl...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
(MedPage Today) -- Combined risk for new cancers except non-melanoma skin cancer with IL-6r inhibitor not significantly different than with TNF inhibitors
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
This study, published Wednesday in the International Journal of Cancer, was the first to pinpoint a specific temperature, according to the authors. Esophageal cancer is the eighth most common cancer in the world and is often fatal, killing approximately 400,000 people every year, according to the International Agency for Research on Cancer. It is usually caused by repeated injury to the esophagus due to smoke, alcohol, acid reflux and — maybe — hot liquids. The esophagus is a long tube through which swallowed food and liquids travel to reach the stomach. The American Cancer Society estimates that 13,750 new cas...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News tea Source Type: news
Authors: Poláková I, Pelák O, Thürner D, Pokrývková B, Tachezy R, Kalina T, Šmahel M Abstract Monitoring immune responses to solid cancers may be a better prognostic tool than conventional staging criteria, and it can also serve as an important criterion for the selection of individualized therapy. Multiparametric phenotyping by mass cytometry extended possibilities for immunoprofiling. However, careful optimization of each step of such method is necessary for obtaining reliable results. Also, with respect to procedure length and costs, sample preparation, staining, an...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Jiang L, Lv L, Liu X, Jiang X, Yin Q, Hao Y, Xiao L Abstract Abnormally expressed microRNAs (miRNAs) contribute widely to human cancer, including oral squamous cell carcinoma (OSCC), by regulating their downstream targets. MiR-223 has been proved to be up-regulated in both gastric cancer and ovarian cancer. However, the effect of miR-223 on OSCC is still unclear. Here, we showed that miR-223 was over-expressed in OSCC tissues using qRT-PCR. Next, we investigated the biological mechanism of miR-223 in OSCC. The results demonstrated that miR-223 facilitated the cell proliferation and migration of OSCC using ...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Esophageal cancer is the eighth most common cancer worldwide and represents the sixth leading cause of global cancer mortality.1 Although esophageal adenocarcinoma (EAC) now accounts for the majority of esophageal cancer diagnosed in the United States, esophageal squamous cell carcinoma (ESCC) remains far more prevalent worldwide. The International Agency for Research on Cancer estimates that 88% of esophageal cancer cases in 2012 were ESCC, with only 12% representing EAC. ESCC exhibits a striking regional variation in incidence, both globally and within a single nation.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Conclusion: Our results revealed that the COX-2 enzymes were expressed, suggesting that they play complementary roles during oral carcinogenesis. In near future researches on administration of chemoradiation therapy combined with COX-2 should be evaluated to improve therapy response.
Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research
ConclusionsWhen combined with ipilimumab, epacadostat ≤50 mg BID demonstrated clinical and pharmacologic activity and was generally well tolerated in patients with advanced melanoma.Trial registrationClinicalTrials.gov identifier,NCT01604889. Registration date, May 9, 2012, retrospectively registered.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Abstract: Genomic analyses in oncologic care allow for the development of more precise clinical laboratory tests that will be critical for personalized pharmacotherapy. Traditional biopsy-based approaches are limited by the availability of sequential tissue specimens to detect resistance. Blood-based genomic profiling (“liquid biopsy”) is useful for longitudinal monitoring of tumor genomes and can complement biopsies. Tumor-associated mutations can be identified in cell-free tumor DNA (ctDNA) from patient blood samples and used for monitoring disease activity. The US Food and Drug Administration approved a li...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Review Articles: Focus on Pharmacodynamic Drug Monitoring Source Type: research
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