The assessment of immune-regulatory effects of extracorporeal photopheresis in leukemic cutaneous T cell lymphoma, graft-versus-host disease and lung transplant rejection

Aims: Although the pathobiology of cutaneous T cell lymphoma (CTCL) is not entirely understood, it is recognized that widespread immune dysfunction is a hallmark of advanced disease. Extracorporeal photopheresis (ECP) is an established first-line therapy for leukemic CTCL (L-CTCL) for>30 years and has also proven successful in several other T cell mediated diseases as well. Our purpose was to study the immunomodulatory effects of ECP by evaluating the cytokine secretion pattern in patients with L-CTCL, graft-versus-host disease (GvHD) or lung transplant rejection (LTPLR) before and after ECP treatment.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research