Indolent hematodermic CD4+ T-cell lymphoma lacking surface CD3 expression: Structural and functional deficiency of T-cell receptor/CD3 complex

We present two patients with indolent cutaneous T-cell lymphoma (CTCL) who had a clonal leukemic fraction of sCD3-, cCD3+, sCD4+ T-cell cells with less cell atypia. The cutaneous lesion of case 1 (60s, female) showed epidermotropic and perivascular infiltration of cCD3+, CD4+ T-cells, the features of which were consistent with those of mycosis fungoides, while in case 2 (50s, male), the diagnosis of CTCL was not confirmed histologically.

Source: European Journal of Cancer - August 29, 2018 Category: Cancer & Oncology Authors: Keiji Iwatsuki, Yuki Nakagawa, Toshihisa Hamada, Takafumi Uchida, Shin Morizane, Takahide Takahashi, Toshiyuki Watanabe, Tomoko Miyake, Keiko Manabe, Kenji Asagoe Source Type: research