Spongiotic mycosis fungoides: Several cases of a rare variant of cutaneous T cell lymphoma

Aim: Mycosis Fungoides (MF) is a cutaneous T-cell lymphoma variant that, in early disease, is often difficult to differentiate from inflammatory dermatoses. Mild spongiosis may be present, but significant spongiosis is exceedingly rare. In a series of 745 biopsies of early/patch MF, only 4% were found to have marked spongiosis. Accepted criteria to confirm MF include epidermotropism of atypical lymphocytes without spongiosis, or epidermotropism out of proportion to any spongiosis that may be present.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research