Microbiome Analysis Possible Aid in Detecting Colon Cancer

This study builds on previous research that showed that patients with an overgrowth of some bacterial species such as Fusobacterium and Bacteroides fragilis is associated with increased risk of colorectal cancer. Likely important protective bacteria that are missing in colons with colorectal cancer are Clostridium, Bacteroides, and Lachnospiraceae. The post Microbiome Analysis Possible Aid in Detecting Colon Cancer appeared first on InsideSurgery Medical Information Blog.
Source: Inside Surgery - Category: Surgery Authors: Tags: Infectious Disease Oncology Bacteroides clostridium colorectal cancer fragilis microbiome Patrick Schloss University of Michigan Source Type: blogs

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Authors: Hernández-Luna MA, López-Briones S, Luria-Pérez R Abstract Worldwide, neoplasms of the gastrointestinal tract have a very high incidence and mortality. Among these, colorectal cancer, which includes colon and rectum malignancies, representing both highest incidence and mortality. While gallbladder cancer, another neoplasm associated to gastrointestinal tract occurs less frequently. Genetic factors, inflammation and nutrition are important risk factors associated with colorectal cancer development. Likewise, pathogenic microorganisms inducing intestinal dysbiosis have become an importan...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Cosmeri Rizzato1, Javier Torres2, Elena Kasamatsu3, Margarita Camorlinga-Ponce2, Maria Mercedes Bravo4, Federico Canzian5 and Ikuko Kato6* 1Department of Translation Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy 2Unidad de Investigación en Enfermedades Infecciosas, Unidades Médicas de Alta Especialidad Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico 3Instituto de Investigaciones en Ciencias de la Salud, National University of Asunción, Asunción, Paraguay 4Grupo de Investigación en Biología del C&aacut...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we identified 37 genus-level core bacteria from feces of 101 healthy mice with different ages, sexes, and mouse strains in three previous studies. They collectively represented nearly half of the total sequences, and predominantly included carbohydrate- and amino acids-metabolizing bacteria and immunomodulatory bacteria. Among them, Anaerostipes indwelt the gut of all healthy mice. Co-abundance analysis showed that these core genera were clustered into five groups (Group C1–C5), which were ecologically related. For example, the abundances of Group C2 including probiotics Bifidobacterium and Lactobacill...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we identified the differentially abundant gut microbes between CRC and healthy samples using the Ratio Approach for Identifying Differential Abundance (RAIDA) algorithm (Sohn et al., 2015). The algorithm fitted the distribution of observed data with a modified zero-inflated lognormal (ZIL) model and estimated the statistical significance of abundance difference by the T-test. Furthermore, we used the GRAMMy algorithm (Xia et al., 2011) to estimate and analyze the relative abundance of gut microbes and diversity of the microbial communities. Finally, we constructed and analyzed a microbial association network...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Na Li, Shimeng Huang, Lili Jiang, Zhaolai Dai, Tiantian Li, Dandan Han and Junjun Wang* State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China Microbial exposure during early life plays a pivotal role in modulating the health and intestinal development of the host. Our recent study showed that the low-birth-weight (LBW) piglets harbored a different fecal microbiota compared to normal-birth-weight (NBW) piglets during early life with a lower abundance of the genus Lactobacillus. Considering the spatial variations in gut microbiota at distin...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consuming an...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionOur results indicated that based on fecal bacterial candidates, statistical simple linear combination model and ROC curve analysis, early detection of AP and CRC might be possible.
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Conclusion: The current study has given an insight into the microbiota of colorectal cancer patients in Saudi Arabia and has identified various genera significantly present in these patients when compared to those of the control group. PMID: 29887882 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic les...
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases reports Source Type: news
CONCLUSIONS Our study provides insights into possible function of gut microbiota in diagnosis and treatment of colorectal cancer. Some bacteria, such as Butyricicoccus, E. coli, and Fusobacterium, can be used as potential biomarkers for normal, adenoma, and cancer groups, respectively. PMID: 28904330 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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