Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

Gasdermin D is a pore-forming protein, which upon activation by inflammasome complexes mediates pyroptotic cell death and IL-1 release. Banerjee et  al. demonstrate a previously unknown regulatory role for gasdermin D-driven K+ efflux in reining in cGAS-dependent type I interferon response to cytosolic DNA.

Source: Immunity - August 28, 2018 Category: Allergy & Immunology Authors: Ishita Banerjee, Bharat Behl, Morena Mendonca, Gaurav Shrivastava, Ashley J. Russo, Antoine Menoret, Arundhati Ghosh, Anthony T. Vella, Sivapriya Kailasan Vanaja, Saumendra N. Sarkar, Katherine A. Fitzgerald, Vijay A.K. Rathinam Tags: Article Source Type: research