Vaccinating against Acne: Benefits  and Potential Pitfalls

Acne vulgaris is treated with antibiotics and retinoids, but side effects are numerous. Novel safe and efficient therapies are still needed. Wang et  al. demonstrate that the secreted virulence factor Christie-Atkins-Munch-Peterson factor 2 from Propionibacterium acnes, a bacterium involved in acne pathogenesis, promotes inflammatory responses. This proinflammatory property could be inhibited by antibodies to Christie-Atkins-Munch-Peterson fact or 2, suggesting Christie-Atkins-Munch-Peterson factor 2 as a candidate target in acne vaccination.

Source: Journal of Investigative Dermatology - August 28, 2018 Category: Dermatology Authors: Emmanuel Contassot Tags: Commentary Source Type: research